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The Elowitz Lab

Publications

Cai, L & Elowitz M. Principles of Systems Biology, No. 13 Cell Systems 2017 (pdf )

Frieda KL, Linton JM, Hormoz S, Choi J, Chow KK, Singer ZS, Budde MW, Elowitz MB, Cai L. Synthetic recording and in situ readout of lineage information in single cells.Nature 2016 March

See Also: News & Views by Lauren Beck and Arjun Raj Nature pdf

Hormoz S, Singer ZS, Linton JM, Antebi YE, Shraiman BI, Elowitz MB. Inferring cell-state transition dynamics from lineage trees and endpoint single-cell Measurements Cell 2016 November; (pdf)

Gao XJ & Elowitz, MB. Synthetic biology: Precision timing in a cell.Nature 2016 March; (pdf)

Kueh HY, Yui MA, Ng KK, Please SS, Zhang JA, Damie SS, Greedman G,Siu SS, Bernstein ID, Elowitz MB, Rothenberg EV. Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment. Nat Immunol 2016 Aug; (pdf)

Lin Y & Elowitz, MB. Central Dogma Goes Digital. Molecular Cell 2016 March; (pdf)

Bintu L, Yong J, Antebi YE, McCue K, Kazuki Y, Uno N, Oshimura M,
and Elowitz MB.
Dynamics of epigenetic regulation at the single-cell level.
Science. 2016 February; (pdf)

See Also: Perspective by Keung & Khalil Science pdf

Lin Y, Sohn CH, Dalal CK, Cai L, Elowitz MB
Combinatorial gene regulation by modulation of relative pulse timing. Nature
2015 October; (pdf)

Markson, JS, Elowitz MB
Synthetic biology of multicellular systems: new platforms and applications for animal cells and organisms. ACS Synth Biol
2014 December; (pdf)

Levine JH, Elowitz MB
Polyphasic feedback enables tunable cellular timers. Curr Biol
2014 October; (pdf)

LeBon L, Lee TV, Sprinzak D, Jafar-Nejad H, Elowitz MB.
Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states.
eLIFE. 2014 September; (pdf)

Dalal CK, Cai L, Lin Y, Rahbar K, Elowitz MB.
Pulsatile Dynamics in the Yeast Proteome.
Curr Biol. 2014 September; (pdf)

Singer ZS, Yong J, Tischler J, Hackett JA, Altinok A,Surani MA, Cai L,
and Elowitz MB.
Dynamic Heterogeneity and DNA Methylation in Embryonic Stem Cells
MOL CELL. 2014 JULY; (pdf)

Tan FE, Elowitz MB
Brf1 posttranscriptionally regulates pluripotency and
differentiation responses downstream of Erk
MAP kinase

PNAS. 2014 Apr; (pdf)

Church GM, Elowitz MB, Smolke CD, Voigt CA, Weiss R.
Realizing the Potential of Synthetic Biology.
Nature Reviews Molecular Cell Biology. 2014 Mar; (pdf)

Levine JH, Lin Y, Elowitz MB.
Functional Roles of Pulsing in Genetic Circuits.
Science. 2013 Dec; (pdf)

Kueh HY, Champhekar A, Nutt SL, Elowitz MB, Rothenberg EV.
Positive Feedback Between PU.1 and the Cell Cycle Controls Myeloid Differentiation
Science. 2013 Jul; (pdf)

Young JW, Locke JCW, Elowitz MB.
Rate of Environmental Change Determines Stress Response Specificity
PNAS. 2013 Jan; (pdf)

Levine JH, Fontes ME, Dworkin J, Elowitz MB.
Pulsed feedback defers cellular differentiation
PLos Biology. 2012 Jan; (pdf)

Young JW, Locke JCW, Altinok A, Rosenfeld N, Bacarian T, Swain S, Mjolsness E, Elowitz MB.
Measuring Single-Cell Gene Expression Dynamics in Bacteria Using Fluorescence Time-lapse Microscopy
Nature Protocols. 2012 Jan; (pdf)
Movies(avi1)

Rosenthal AZ, Elowitz MB.
Following Evolution of Bacterial Antibiotic Resistance in Real Time
Nature Genetics. 2012 Jan; (pdf)

Locke JCW, Young JW, Fontes M, Jiménez MJH, Elowitz MB.
Stochastic Pulse Regulation in Bacterial Stress Response
Science. 2011 Oct; (pdf)

Nandagopal N, Elowitz MB.
Synthetic Biology: Integrated Gene Circuits
Science. 2011 Sep; (pdf)

Sprinzak D, Lakhanpal A, LeBon L, Garcia-Ojalvo J, Elowitz MB.
Mutual Inactivation of Notch Receptors and Ligands Facilitates Developmental Patterning
PLoS Comp. Bio. 2011 Jun; (pdf)

Young JW, Elowitz MB.
Mixed messages: how bacteria resolve conflicting signals
Mol. Cell. 2011 May; (pdf)

Elowitz MB, Lim WA.
Build life to understand it
Nature. 2010 Dec; (pdf)

Acar M, Pando BF, Arnold FH, Elowitz MB, van Oudenaarden A.
A general mechanism for network-dosage compensation in gene circuits
Science. 2010 Sep; (pdf)
Supp(pdf)

Eldar A, Elowitz MB.
Functional roles for noise in genetic circuits
Nature. 2010 Sep; (pdf)

Cox RS III, Dunlop MJ, Elowitz MB.
A synthetic three-color scaffold for monitoring genetic regulation and noise
J Biol Eng. 2010 Jul; (pdf)

Lankhanpal A, Sprinzak D, Elowitz MB.
Mutual inactivation of Notch and Delta permits a simple mechanism for lateral inhibition patterning
q-bio.MN. 2010 Jul; (pdf)

Sprinzak D, Lakhanpal A, LeBon L, Santat LA, Fontes ME, Anderson GA, Garcia-Ojalvo J, Elowitz MB.
Cis-interactions between Notch and Delta generate mutually exclusive signalling states
Nature. 2010 May; (pdf)
Supp(pdf) Movies(avi1),(avi2),(avi3)

Çagatay T, Turcotte M, Elowitz MB, Garcia-Ojalvo J, Süel GM.
Architecture-dependent noise discriminates functionally analogous differentiation circuits
Cell. 2009 Oct; (pdf)
Supp(pdf)

Eldar A, Chary V, Xenopoulos P, Fontes ME, Loson OC, Dworkin J, Piggot P, Elowitz MB.
Partial penetrance facilitates developmental evolution in bacteria
Nature. 2009 Jul; 460(7254):510-514. (pdf)

Locke JCW, Elowitz MB.
Using movies to analyse gene circuit dynamics in single cells
Nat Rev Micro. 2009 May;7(5):383-392. (pdf)

Dunlop MJ, Cox RS III, Levine JH, Murray RM, Elowitz MB.
Regulatory activity revealed by dynamic correlations in gene expression noise
Nature Genetics. 2008;40:1493-1498. (pdf)
Supp(pdf) Movies(avi1),(avi2)

Cai L, Dalal CK, Elowitz MB.
Frequency-modulated nuclear localization bursts coordinate gene regulation
Nature. 2008 Sep 25;455(7212):485-490. (pdf)
Supp(pdf) Movie(avi)

Presser A, Elowitz MB, Kellis M, Kishony R.
The evolutionary dynamics of the Saccharomyces cerevisiae protein interaction network after duplication
Proc Natl Acad Sci USA. 2008 Jan 22;105(3):950-4. (pdf)

Cox RS III, Surette MG, Elowitz MB.
Programming gene expression with combinatorial promoters
Mol Syst Biol. 2007 Nov 13;3:145. (pdf)

Rosenfeld N, Young JW, Alon U, Swain PS, Elowitz MB.
Accurate prediction of gene feedback circuit behavior from component properties
Mol Syst Biol. 2007 Nov 13;3:143. (pdf)

Süel GM, Kulkarni RP, Dworkin J, Garcia-Ojalvo J, Elowitz MB.
Tunability and noise dependence in differentiation dynamics
Science. 2007 Mar 23;315:1716-1719. (pdf) Supp. (pdf)

Rosenfeld N, Perkins TJ, Alon U, Elowitz MB, Swain PS.
A fluctuation method to quantify in vivo fluorescence data
Biophys. J. 2006 Jul 15;91(2):759-66
.

Süel G, Garcia-Ojalvo J, Liberman L, Elowitz MB.
An excitable gene regulatory circuit induces transient cellular differentiation
Nature. 2006 Mar 23;440:545-50. [Letters] (pdf)

Sprinzak D, Elowitz MB.
Reconstruction of genetic circuits
Nature. 2005 Nov 24;438(7067):443-8. [Review] (pdf)

Eldar A, Elowitz MB.
Systems biology: deviations in mating
Nature. 2005 Sep 29;437(7059):631-2. [News & Views] (pdf)

Rosenfeld N, Young JW, Alon U, Swain PS, Elowitz MB.
Gene regulation at the single-cell level
Science. 2005 Mar 25;307(5717):1962-5. (pdf)

Garcia-Ojalvo J, Elowitz MB, Strogatz SH.
Modeling a synthetic multicellular clock: repressilators coupled by quorum sensing
Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):10955-60. Epub 2004 Jul 15. (pdf)

Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, Alon U.
Dynamics of the p53-Mdm2 feedback loop in individual cells
Nat Genet. 2004 Feb;36(2):147-50. Epub 2004 Jan 18. (pdf)

Overholtzer M, Rao PH, Favis R, Lu XY, Elowitz MB, Barany F, Ladanyi M, Gorlick R, Levine AJ.
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability
Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11547-52. Epub 2003 Sep 12. Erratum in: Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14511.

Rosenfeld N, Elowitz MB, Alon U.
Negative autoregulation speeds the response times of transcription networks
J Mol Biol. 2002 Nov 8;323(5):785-93. (pdf)

Swain PS, Elowitz MB, Siggia ED.
Intrinsic and Extrinsic Contributions to Stochasticity in Gene Expression
Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12795-800. Epub 2002 Sep 17. (pdf)

Elowitz MB, Levine AJ, Siggia ED, Swain PS.
Stochastic Gene Expression in a Single Cell
Science. 2002 Aug 16;297(5584):1183-6. (pdf)

Guet CC, Elowitz MB, Hsing W, Leibler S.
Combinatorial Synthesis of Genetic Networks
Science. 2002 May 24;296(5572):1466-70. (pdf)

Elowitz MB, Leibler S.
A Synthetic Oscillatory Network of Transcriptional Regulators
Nature. 2000 Jan 20;403(6767):335-8. (pdf)


Elowitz MB, Surette MG, Wolf PE, Stock JB, Leibler S.
Protein Mobility in the Cytoplasm of Escherichia Coli
J Bacteriol. 1999 Jan;181(1):197-203. (pdf)

Surrey T, Elowitz MB, Wolf PE, Yang F, Nedelec F, Shokat K, Leibler S.
Chromophore-assisted light inactivation and self-organization of microtubules and motors
Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4293-8. (pdf)

Elowitz MB, Surette MG, Wolf PE, Stock J, Leibler S.
Photoactivation Turns Green Fluorescent Protein Red
Curr Biol. 1997 Oct 1;7(10):809-12. (pdf)

Bourdieu L, Duke T, Elowitz MB, Winkelmann DA, Leibler S, Libchaber A.
Spiral defects in motility assays: A measure of motor protein force
Phys. Rev. Lett. 1995 75(1):176-179.

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